A mathematician is a machine for turning coffee into theorems. - Alfréd Rényi
After pulling an allnighter last night, in order to stay awake during the day i needed huge amounts of coffee.
So i decided to write a post (the first of a series of posts on this subject) about the neurological effects of this miraculous drug called caffeine.
<WARNING - Organic Chemistry>
Caffeine is trimethylxanthine and is found in plants to protect them from various insects.
It is metabolized in the liver, to 3 dimethylxanthines (replacing CH3 with H) which have their own distinct but physiological effects :
Paraxanthine, Theobromine and Theophylline
So, how does caffeine works?
Caffeine has a similar structure to adenosine, which is used in ATP and ADP (the “energy credits” of the cells) and is also an inhibitory neurotransmitter. As neurotransmitter, the main action of adenosine is probably to promote sleep.
(HINT: A receptor is a protein in the cell. where molecules can bind and promote a cellular response)
Due to the similar structure, after crossing the blood brain barrier (or : when it is in the brain) caffeine acts as an antagonist of the A1 and A2A adenosine receptors (and Theophylline acts as an antagonist for the other two). This means, that it binds on the receptors, and prohibits the adenosine binding. This fact stimulates the release of dopamine.
Furthermore, caffeine increases the production of serotonin, epinephrine and gastric acid.
The main effects of the 3 metabolites of caffeine are :
Paraxantine : Increases lipolysis (”more energy for the muscles”)
Theobromine : Dilates the vessels, resulting in increased supplies of oxygen and nutrients to the brain and the muscles.
Theophylline : Increases heart rate and efficiency.
Dopamine is a neurotransmitter, which bind on the Dopamine receptors, who control motivation, pleasure and learning.
Dopamine in the mesolimbic pathway (a neural pathway of the brain) decreases latent inhibition and promotes arousal.
This facts, induce the creativity and idea generation. However, very high levels of dopamine in the mesolimbic pathway are connected with psychosis and schizophrenia.
</WARNING - Organic Chemistry>
The subject of Creativity, Caffeine, and Latent Inhibition which was the main reason i was prompted to write about caffeine, will be addressed in a later post.
P.S. Biochemistry is a topic where my knowledge is really limited. So most of my information for writing this post came from books and Internet. I found writing this post a good exercise of writing for something you don’t know much, while avoiding plagiarism.